Aft1 nuclear translocation

3 papers1 finding

Cells3

Interventions

1

Caloric restriction

downin yeast cells1

1 study

Caloric restriction prevents Aft1 nuclear translocation in yeast cells.
“The nuclear translocation of the Aft1 transcriptional regulator of the iron regulon occurred during aging in a manner that predicted remaining lifespan, but was prevented by CR.”
Cellsduring aging
Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake
eLife13 Oct 2025Preprint

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