AFF4 phosphorylation

1 paper1 finding

Animals1

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1

Insulin resistance

downin mice1

1 study

Insulin resistance decreases AFF4 phosphorylation in mice.
“phosphorylation of S831 on AFF4 is an insulin-dependent substrate of P70S6K and attenuated in aged, IR bone.”
Animalsin aged, IR bonebone
Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator
Nature communications31 Dec 2025

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Nature Communications1 Jan

Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator

Experiments in miceBones and joints