Active zone density

Advanced age is associated with active zone density in mice.

“the active zone (AZ) density significantly decreased in NMJs at 30 months, compared to 4- and 26-month-old mice.”

Animalsneuromuscular junction

Ageing-induced weakness of mouse NMJs is associated with reduced active zone density, synaptic event kinetics and presynaptic calcium entry

The Journal of physiology·10 Aug 2025