Acquired TERT promoter mutation

Biomarker

1 paper2 findings

  • Humans1

Effects

1

Survival

no changein humans1

1 study
  1. Acquired TERT promoter mutation has no effect on survival in humans.

    “Survival did not differ between patients with and without an acquired mutation.”

    HumansGermline telomere-related gene mutation carriers after lung transplantationn = 34

    Clinical impact of TERT somatic mutation in telomerase-related gene mutation carriers after lung transplantation

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation19 Jun 2022

Associations

1

Myelodysplasia after lung transplantation

downin humans1

1 study
  1. Acquired TERT promoter mutation is associated with myelodysplasia after lung transplantation in humans (1 of 8 patients with a mutation versus 7 of 18 without a mutation).

    “myelodysplasia developed in only 1 of 8 patients with an acquired TERT promoter mutation versus 7 of 18 patients without a mutation.”

    HumansGermline telomere-related gene mutation carriers after lung transplantation

    Clinical impact of TERT somatic mutation in telomerase-related gene mutation carriers after lung transplantation

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation19 Jun 2022

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