Abnormal white matter volume

1. Coronary artery calcium score has no effect on abnormal white matter volume in humans (p = 0.059).

   “CAC showed only a marginal association (p = 0.059).”

   Humansbrainn = 84

   Low-Density Lipoprotein Cholesterol Is Independently Associated with White Matter Injury Beyond Coronary Artery Calcium: Insights into Brain Aging

   Journal of clinical medicine·25 Apr 2026

More on Coronary artery calcium score

1. Low-density lipoprotein cholesterol is associated with abnormal white matter volume in humans (β = 0.006, 95% CI: 0.002-0.010).

   “In fully adjusted models, LDL-C remained the only independent predictor (β = 0.006, 95% CI: 0.002-0.010, p = 0.007; standardized β = 0.225; partial R2 = 11.7%)”

   Humansfully adjusted modelbrainn = 69

   Low-Density Lipoprotein Cholesterol Is Independently Associated with White Matter Injury Beyond Coronary Artery Calcium: Insights into Brain Aging

   Journal of clinical medicine·25 Apr 2026

More on Low-density lipoprotein cholesterol