Brain
Blood protein linked to dementia risk beyond key markers
An observational study of 259 people with cognitive difficulties linked higher blood protein levels to later dementia and death beyond some established Alzheimer’s…An observational study of 259 people with cognitive difficulties linked higher blood protein levels to later dementia and death beyond some established Alzheimer’s markers.
Cohort · 185 peopleDementia
Who was studied185 non-demented people with subjective or mild cognitive impairment
What changedDementia risk rose with blood β-synuclein (hazard ratio 1.40 per standard-deviation increase), with little change after accounting for amyloid and tau
The catchThe dementia association did not survive adjustment for continuous pTau181 normalized to CSF Aβ40