Mehdi Bouhaddou
University of California, Los Angeles2 papersORCID 0000-0002-9526-1427OpenAlex
Papers
bioRxivAnimalsPreprint
Senescent CD4 T cells drive age-associated autoimmunity in mice and humans
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.
bioRxivAnimalsPreprint
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with…Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.