400+ results
In mice, genetically removing the protein reduced signs of cellular aging across multiple tissues and limited hallmarks of blood stem cell aging.In mice, genetically removing the protein reduced signs of cellular aging across multiple tissues and limited hallmarks of blood stem cell aging.
A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.
In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated…In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated oxidative stress.
In mice lacking ovaries to mimic estrogen loss, deleting the Camkk1 gene from bone-degrading cells attenuated the loss of spongy bone.In mice lacking ovaries to mimic estrogen loss, deleting the Camkk1 gene from bone-degrading cells attenuated the loss of spongy bone.
In 35,193 healthy adults followed for over a decade, each one-unit score rise was linked to a hazard ratio of 2.60 for disease progression.In 35,193 healthy adults followed for over a decade, each one-unit score rise was linked to a hazard ratio of 2.60 for disease progression.
An experiment spanning 16 combinations of age, sex and infection stage also found persistent inflammatory responses in older male mice at later stages.An experiment spanning 16 combinations of age, sex and infection stage also found persistent inflammatory responses in older male mice at later stages.
A three-region model scored 0.81 versus 0.79 for a whole-brain model on a measure of how well it ranked death risk.A three-region model scored 0.81 versus 0.79 for a whole-brain model on a measure of how well it ranked death risk.