Papers by R Tian

18 results

  1. JAMA Neurology

    Hearing aids did not cut dementia conversion in older adults

    Over 24 months, dementia conversion was 3.09% with hearing aids compared with 4.74% with hearing care education, a non-significant difference.Over 24 months, dementia conversion was 3.09% with hearing aids compared with 4.74% with hearing care education, a non-significant difference.

    Randomised trial in 703 peopleDementia
  2. Advanced Science

    Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice

    The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic…The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic deficits.

    Experiments in miceHuntington's disease