bioRxiv
A neuronal CRISPRi screen identifies PQLC2 as a lysosomal pH regulator controlling tau homeostasis
Preprint: experiments in cellsMechanisms
Abstract
Lysosomes make key contributions to the maintenance of cellular proteostasis, and their functional compromise has been linked to aging and neurodegenerative disease. A defining characteristic of lysosomes is their relative acidity compared to other subcellular compartments, a quality that enables the efficient breakdown of macromolecules.
The paper
University of California, San Francisco
bioRxiv, 31 Aug 2026, CC BY, Preprint, not peer-reviewed
