Papers by Fan Fan

400+ results

  1. Nature Neuroscience

    Genetic data highlight potential drug targets for Alzheimer's

    A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.

    Mendelian randomisation in 111,680 peopleAlzheimer's disease
  2. Nature Communications

    Early overfeeding speeds muscle loss and shortens life in mice

    Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.

    Experiments in miceMuscle
  3. Research Square

    Higher estimated artery stiffness linked to higher cancer risk

    The adjusted hazard ratio—a comparison of cancer rates over time—was 1.48 for higher versus lower estimated artery stiffness.The adjusted hazard ratio—a comparison of cancer rates over time—was 1.48 for higher versus lower estimated artery stiffness.

    Preprint: cohort study of 11,648 peopleCancer
  4. Medical Image Computing and Computer-assisted Intervention

    Model estimates brain aging speed from local MRI changes

    Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.

    Computational studyBiomarkers