Preprints.org
Weight Regain During Continued Incretin Therapy Is Associated With an Inflammatory Signature at Weight Nadir and Higher Cardiovascular Event Rates
Preprint: cohort study of 58,618 peoplePopulations
Abstract
For patients treated with semaglutide or tirzepatide, weight-loss plateau followed by regain is a major concern, yet rebound occurring while treatment continues to be documented remains underappreciated and its biological correlates are poorly understood.
The paper
Preprints.org, 21 Aug 2026, CC BY, Preprint, not peer-reviewed

