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Catalpol improves senile osteoporosis by promoting osteogenesis and inhibiting bone resorption through the PI3K/AKT signaling pathway

By Zenghui Tian, Kaiying Cui, Yuxiao Tian, Show 4 more authorsYingying Li
Preprint: experiments in animalsInterventions
Paper

Abstract

Senile osteoporosis (SOP) is core pathology is the imbalance between bone formation and bone resorption, which leads to reduced bone mass and increased bone fragility. Catalpol possesses various biological activities such as antioxidant and anti-inflammatory effects. However, the mechanism by which it improves SOP remains unclear.

The paper

Zenghui Tian, Kaiying Cui, Yuxiao Tian, Show 4 more authorsYingying Li

Shandong University of Traditional Chinese Medicine; Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Research Square, 14 Aug 2026, CC BY, Preprint, not peer-reviewed

doi.org/10.21203/rs.3.rs-9974943/v1

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