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Ellagitannin corilagin targets V-ATPase B2 to restore lysosomal Ca²⁺-AMPK metabolic axis and suppress microglia-driven neuroinflammation in aging mice

By Chenxi Yue, Ruixiang Li, Zhang Sang, Show 3 more authorsPeng Chen
Preprint: experiments in animalsInterventions
Paper

Abstract

This research sought to assess the prophylactic effects of corilagin (CORG), an ellagitannin, on D-galactose (D-gal) neurodegeneration associated with aging and to elucidate the underlying mechanisms.

The paper

Chenxi Yue, Ruixiang Li, Zhang Sang, Show 3 more authorsPeng Chen

Renmin Hospital of Wuhan University

Research Square, 3 Aug 2026, CC BY, Preprint, not peer-reviewed

doi.org/10.21203/rs.3.rs-10542735/v1

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