Genetic Associations Among Appendicular Lean Mass, Alanine Aminotransferase, and Type 2 Diabetes: Multi-Dataset Mendelian Randomization and Colocalization at the SERPINA1 Candidate Locus

Abstract

Background/Objectives: Appendicular lean mass (ALM), alanine aminotransferase (ALT), and type 2 diabetes (T2D) may be genetically linked. However, the ALT-related pathway and shared signals at the SERPINA1 candidate locus remain uncertain.

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