JCI Insight

Human Y chromosome pan-organ mapping reveals progressive mosaic loss from normal to cancer

By Arkadiusz Gertych, Huihui Ye, Xingyu Chen, Dan Theodorescu

Graphical abstract from JCI Insight — Graphical abstract. Gertych et al.

Cohort study of 405 peopleBiomarkers

Declared no competing interests

The paper

Arkadiusz Gertych, Huihui Ye, Xingyu Chen, Dan Theodorescu

Department of Pathology and Laboratory Medicine; University of Arizona Cancer Center

JCI Insight, 8 Sep 2026

doi.org/10.1172/jci.insight.201996 PubMed 42708362

Communications Biology4 Oct 2026
Partial Y chromosome loss alters transcription in cancer cells
bioRxiv7 Oct 2026
Y chromosome loss linked to advanced pancreatic cancer
bioRxiv9 Oct 2026
Loss of the Y chromosome barely alters tumour gene activity
medRxiv2 Oct 2026
Inherited genetic variants influence age-associated mosaic chromosomal errors in human blood