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Science Advances

IDE-mediated GLP-1 degradation as the basis for designing long-acting and CNS-stable GLP-1 receptor agonists

By Lu Zhang, Xinyi Liu, Chenfang Si, +6Show 6 more authors, Yaoyang Zhang
Experiments in animalsInterventions
Paper

The paper

Lu Zhang, Xinyi Liu, Chenfang Si, +6Show 6 more authors, Xianglong Hou, Xintian Hu, Yelin Chen, Junhao Hu, Christoph W. Turck, Bing Shan, Yaoyang Zhang

Chinese Academy of Sciences

Science Advances, 26 Aug 2026

doi.org/10.1126/sciadv.aeh4670PubMed 42647645

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