The dark side of the matrix: Elastin-derived fragments drive aging by igniting the immune system

The extracellular matrix (ECM) undergoes extensive alterations during aging, yet its contribution to organismal aging remains partially understood. Emerging evidence now identifies elastin-derived fragments as bioactive matrikines that function as systemic drivers of inflammaging and aging, rather than passive byproducts of tissue degradation. This Viewpoint examines recent findings on elastin-derived fragments in the context of matrikine biology and aging, highlighting their emerging roles as mediators of inflammaging and systemic aging. It further discusses the implications of these discoveries for understanding the mechanisms of aging and explores their potential to inspire novel therapeutic strategies for age-related diseases.