Renal aging: research models, interventions and development trends

The aging kidney is both a prime target of age-related damage and an independent risk factor for renal diseases; as populations grow older, chronic kidney disease in the elderly has become a major emerging health threat. Over recent decades, our understanding of the molecular and cellular mechanisms behind the changes associated with renal aging and age-related diseases has expanded dramatically, revealing the potential role of these changes in renal aging. This review summarizes the pathological alterations that occur in the aging kidney, systematically explores the disease models of renal senescence and the potential delaying strategies, and provides a theoretical reference for future research on kidney aging and the prevention of age-related renal diseases.