npj Aging
Do we actually need aging clocks?
By Dmitrii V. Kriukov, Evgeniy Efimov, Mikhail Sergeevich Gelfand, Alexey A. Moskalev, Ekaterina E. Khrameeva
ReviewBiomarkers
Abstract
Aging clocks use machine learning to estimate biological age as a proxy for general health state. Here, we critically examine their practical value, highlighting fundamental challenges: abstract definitions, inconsistent clinical validation, and ignored prediction uncertainty. By comparing aging clocks with expert risk scores, direct outcome predictors, and emerging large health models, we question their benefits and encourage researchers to explicitly justify clock advantage over established alternatives, ensuring truly actionable insights.
The paper
Skolkovo Institute of Science and Technology
npj Aging, 19 Dec 2025


