The antioxidant effect of resveratrol on leukocytes from patients with Alzheimer is independent of SIRT1 signaling pathway

Alzheimer's Disease (AD) is the most prevalent dementia in aging. Among its aspects is cognitive and functional decline, resulting from an increase in Reactive Oxygen Species (ROS) and Nitrogen (RNS). Resveratrol (RSV) is a polyphenolic compound that has been recognized as a potent antioxidant. The objective was to verify the oxidative profile of AD in leukocytes, correlating the main oxidative parameters with the functionality of these elderly individuals and verify the antioxidant effect of RSV. For this, ROS and RNS, the antioxidant enzymes catalase and glutathione peroxidase (GPx), as well as the action of the SIRT1 on leukocytes of elderly people without and with AD, in the presence and absence of RSV, were evaluated. It was observed that RSV, despite acting in the AD group, had its antioxidant power reduced compared to the group without AD. RSV was able to increase GPx in both groups. Analyzing SIRT1, we observe the silencing of this signaling pathway in leukocytes from AD. AD was more dependent on the Katz index. Therefore, we observed that oxidative stress predisposes to an increased loss of autonomy and independence in AD and that the antioxidant effect of RSV is reduced.