Physical activity attenuated the association of air pollutants with telomere length in rural Chinese adults

BACKGROUND: Exposure to air pollutants (nitrogen dioxide (NO₂) and particulate matters (PMs)) or physical inactivity is linked to telomere length (TL) shortening. However, there is a lack of research on combined effects of either NO₂ or PMs and physical activity (PA) on TL. This study aimed to explore the joint associations of air pollutants (NO₂ or PMs) and PA with relative TL in rural Chinese adults. METHODS: This study was conducted among 2704 participants aged 18-79 years in rural China. Concentrations of NO₂ and PMs (PM with an aerodynamics diameter ≤ 1.0 μm (PM₁), ≤2.5 μm (PM2.5) or ≤10 μm (PM₁₀)) were estimated using random forest models incorporated with satellites data, meteorological data, and land use information. Relative TL of each participant was measured by a quantitative real-time polymerase chain reaction. Linear regression models were applied to examine the independent associations between PA, NO₂ or PMs and relative TL. Interaction plots were used to depict the altered associations between NO₂, PM₁, PM2.5, or PM₁₀ and relative TL along with increasing PA levels. RESULTS: Each 1 μg/m³ increment in NO₂, PM₁, PM2.5, or PM₁₀ was associated with a 0.038 (95% confidence intervals (CI): -0.044, -0.033), 0.036 (95% CI: -0.041, -0.031), 0.052 (95% CI: -0.059, -0.045), or 0.022 (95% CI: -0.025, -0.019) decrease in relative TL among all participants; similar findings were observed among normal glucose tolerance or impaired fasting glucose (IFG) participants as well as type 2 diabetes mellitus (T2DM) patients. PA at certain levels counteracted the association of air pollutants (NO₂, PM₁, PM2.5, and PM₁₀) with relative TL among IFG participants or T2DM patients. CONCLUSIONS: Long-term exposure to NO₂ and PMs was associated with relative TL shortening and these effects may be counteracted by PA at certain levels in IFG participants or T2DM patients.