Continuous Glucose Monitoring as Assessment Tool for Diagnosis of Prediabetes State

Introduction and Objective: The oral glucose tolerance test (OGTT) is used for diagnosis of carbohydrate abnormalities. Continuous Glucose Monitoring (CGM) is already routinely used in diabetes patients for control assessment, but it is also used for determining early prediabetes. The objective is to estimate the ability to use CGM for carbohydrate disorders diagnosis when observing prediabetes. Methods: 109 patients (57 women, mean age 40.01±8.87 years) performed CGM by using DexcomONE+ for ten days and consequent OGTT afterwards. Mean weight was 89.07±12.73 kg, mean BMI was 32.86±2.0 kg/sq.m. and mean HbA1c 5.58±0.38 %. Results: For assessment of diagnostic potency of CGM we compared time-above-the-range (TAR), time-within-the-range (TIR) and fasting and 120th minute glucose level. 75 patients were with normal glucose tolerance according to OGTT. Of them 20% were with higher TAR (>5.0%) and showed abnormal increase in glucose level usually after meal. 7 patients were diagnosed with diabetes based on OGTT and were excluded from data assessment. In patients with diagnosed impaired glucose tolerance or with increased fasting glucose, CGM showed increased time above the set range (TAR) of 7.8 mmol/l and area above the curve (phi=0.78, p<0.05). Conclusion: CGM reveals additional opportunities for early prediabetes diagnosis as OGTT is omitting approximately 20 % of case with changes in glucose profile. CGM could lead to appropriate recommendations and treatment. Disclosure: T. Totomirova: None. M. Arnaudova: None. N. Kostadinov: None.