Evolving Pattern of Mortality Trend Due to Diabetes with Peripheral Vascular Complications in the United States from 1999–2020—A Benchmarking Analysis from the CDC WONDER Database

Introduction and Objective: DM ranks as 6th leading cause of mortality in the USA with annual costs $412.9 billion. Strict blood sugar control may reduce vascular complications and related fatalities. Methods: Using underlying cause of death certificate data(CDC WONDER database), we analyzed deaths due to DM with peripheral circulatory complications (PCC) stratified by age, sex, year, race, and place of death in patients aged ≥ 25 years in USA(1999-2020). Results: The annual percentage of change (APC) in total number of death decreased by 3.65% in male while in female by 6.44% per year from 1999-2020. State wise, Alaska & Nevada saw increases of +4.66% and +3.06% per year, respectively, while other states showed a decline. Census-wise, the West experienced the highest increase in total deaths with an APC of +13.54% per year. Based on urbanization, Micropolitan (Nonmetro) areas observed the highest increase at +13.51%. Age-wise, the 25-34 age group experienced the steepest annual rise in diabetes-related deaths. Among racial groups, Asian or Pacific Islanders saw the highest annual increase in mortality rates. Conclusion: Deaths due to DM linked to PCC represented 6.93% of all DM related fatalities. Notably, the study revealed a consistent decline in mortality rates among all demographics, with the exception of increases in specific states and among Asian or Pacific Islander populations. Disclosure: M. Kaur: None. D. Gupta: None. A. Patel: None. G. Gopi: None. A. Rathi: None. A. Shandilya: None. R. Daoud: None. M. Abubaker: None. J. Patel: None. H. Desai: None.