Trends and Disparities in Hypoglycemia Related Mortality across the U.S. from 1999 to 2020—Insights from the CDC Wonder Database

Introduction and Objective: Recent advancements in diabetes management have paradoxically coincided with a persistently high incidence of severe hypoglycemia, highlighting a critical gap in patient safety and treatment efficacy. Methods: Using death certificate data from the CDC WONDER database, we analyzed deaths due to Hypoglycemia stratified by age, sex, year, race, and place of death in patients aged ≥ 25 years in USA from 1999-2020. The results are expressed in terms absolute counts. Results: From 1999-2020, the annual percentage change (APC) in total deaths increased by 5.24% for males and 5.42% for females. Regionally, the South recorded the highest increase in death count with an APC of 6.19%. Racially, Asians or Pacific Islanders saw the highest annual increase in mortality rates at 7.18%. Age-wise, the 55-74 age group showed the highest increase in APC, highlighting increased vulnerability among older adults. Urbanization-wise, fringe metropolitan and smaller non-metropolitan areas experienced the most significant annual rises in hypoglycemia-related mortality. Conclusion: In conclusion, the observed increased disparities in hypoglycemia-related mortality underscore the need for tailored public health strategies, particularly in non-metropolitan areas and among older adults, to effectively mitigate these risks and improve health outcomes. Disclosure: R. Daoud: None. P. Adrejiya: None. S. Purohit: None. F. Suhani: None. S.S. Sharma: None. M. Kaur: None. G. Gopi: None. A. Shandilya: None. M. Abubaker: None. V. Amin: None. H. Desai: None.