Dismantling the Tumor Microenvironment: Vitamin B3 as a Tri-Partite Adjuvant to Overcome Fusobacterium nucleatum and Warburg Metabolism in GI Oncology – Shattering the Bacterial-Warburg Loop

This repository contains the conceptual framework, structural models, and literature synthesis for the manuscript: "Dismantling the Tumor Microenvironment: Vitamin B3 as a Tri-Partite Adjuvant to overcome Fusobacterium nucleatum and Warburg Metabolism in GI Oncology. This project investigates a novel biochemical strategy using Vitamin B3 (Nicotinamide/Niacin) to disrupt F. nucleatum biofilms via class III sirtuin inhibition, restore host immune NAD+ bioenergetics via GPR109A, and normalize chaotic tumor vasculature through prostaglandin-mediated (PGD2/PGE2) vasodilation. Included are high-resolution schematic illustrations (Figure 1) and methodological data-sourcing matrices.