Gerotherapeutic compound picolinic acid supports locomotor function and bone health in aged zebrafish

Abstract

Objectives: This study aimed to evaluate the impact of picolinic acid (PIC), a metabolite derived from tryptophan, on age-related tissue regeneration and physical decline in zebrafish. Additionally, it examined changes in whole-body mass index (WB-BMI) as an indicator of musculoskeletal aging.