Single-Nucleus RNA Sequencing Reveals Muscle Fiber Cell Heterogeneity during Human Skeletal Muscle Aging

GSA 2025 Abstract

Abstract

Skeletal muscle aging is characterized by a progressive decline in muscle mass and function, yet its cellular and molecular mechanisms remain incompletely understood.

Single-cell omics
Extracellular matrix remodelling
Hypoxia and HIF signalling
Muscle atrophy
CD99
Humans

The paper

Wu L, Gong C, Wang A et al.

GSA 2025 Abstract · 31 Dec 2025 · CC BY

Presented at GSA 2025

doi.org/10.1093/geroni/igaf122.235

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Single-Nucleus RNA Sequencing Reveals Muscle Fiber Cell Heterogeneity during Human Skeletal Muscle Aging

Abstract

The paper

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