EPIGENETIC AGING AND XENOBIOTIC METABOLISM IN THE MOUSE LIVER

Abstract

Hepatic xenobiotic metabolism declines with age, and while intact metabolism is associated with longevity, few studies have explored the genome-wide impact of epigenetic aging on these processes. In this study, we used liver tissues from male C57BL/6 mice (4, 24, and 32 months), obtained from the National Institute on Aging.