PATHOGENIC PRE-LEUKEMIC MUTATIONS: RARE IN CLONAL HEMATOPOIESIS BUT ENRICHED IN MYELOID DISEASES

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) refers to the expansion of peripheral blood cells derived from hematopoietic stem cells (HSCs) with at least one somatic driver mutation in healthy elderly individuals. CHIP is strongly linked to aging and confers an increased risk for blood cancers, non-hematological diseases (e.g.