PD1 BLOCKADE IMPROVES SURVIVAL AND CD8+ CYTOTOXIC CAPACITY, WITHOUT INCREASING INFLAMMATION, DURING NORMAL MICROBIAL EXPERIENCE IN OLD MICE

Abstract

The elderly and those with chronic diseases have a 2 to 10-fold increased risk of hospitalization and mortality following infection as compared with healthy adults. A significant contributor to disease severity is the aging of the immune system, including an expansion of exhausted T cells.