The impact of AI correction on Centiloid in a same subject visual read comparison of ¹⁸ F‐Florbetapir and ¹⁸ F‐NAV4694 Aβ PET

Abstract

Background: Visual read of Aβ PET remains standard clinical practice. ¹⁸ F‐NAV4694 (NAV) has high affinity for Aβ and low non‐specific binding so may be more accurate than older Aβ tracers. We compared visual read of NAV to ¹⁸ F‐Florbetapir (FBP) PET using standard and AI corrected Centiloid (CL) thresholds as gold standard.