Segmentation and registration of within‐subject 7 tesla ex vivo and 3 tesla in situ MRI to increase sensitivity of imaging biomarkers

Abstract

Background: Understanding pathological contribution in mixed etiology dementia and atypical Alzheimer’s disease remains challenging. However, in‐vivo MRI and neuropathology studies are hampered by the years of delay between MRI and brain autopsy. Postmortem in‐situ MRI is a good proxy to mitigate this problem (Frigerio et al.

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