AAIC 2025 Abstract

Reanalysis of the A4 Study to Formally Evaluate Amyloid Removal as a Surrogate for Cognitive Decline

Trial in peopleInterventions

Abstract

Background: Amyloid removal has been used as surrogate outcomes in clinical trials of Alzheimer’s disease (AD) drugs, leading to approvals of aducanumab and lecanemab under the Accelerated Approval Program.

The paper

Brown University; Harvard University

AAIC 2025 Abstract, 23 Dec 2025, CC BY

Presented at AAIC 2025

doi.org/10.1002/alz70862_110201