Upregulation of tRF‐19‐J in Anti‐Aβ Therapy‐Related ARIA Among Alzheimer's Disease Patients and Its Role in Promoting Ubiquitin‐Mediated Degradation of Connexin 43 in Brain Endothelial Cells

Abstract

Background: Amyloid‐related imaging abnormalities (ARIA) are serious complications commonly observed during anti‐Aβ monoclonal antibody therapy for Alzheimer's disease (AD). Disruption of blood‐brain barrier (BBB) permeability is considered a key mechanism in ARIA development.

The paper