White matter hyperintensities are associated with glymphatic impairment and antioxidant pathway in healthy aging

Abstract

Background: White matter hyperintensities (WMHs), a marker of vascular‐brain injury in older adults, constitute an Alzheimer's disease (AD) risk‐factor (Debette et al. , 2019). Recent studies in AD associate WMHs to (a) enlarged choroid plexus (ChP) (Hong et al.