Evaluating CSF NfL and Hippocampal Atrophy as Predictors of Dementia Progression: A 20‐Year Longitudinal Study

Abstract

Background: Neuroinflammation is a key risk factor in dementia pathogenesis. Biomarkers such as cerebrospinal fluid (CSF), neurofilament light (NfL), and MRI‐derived hippocampal volume provide insights into early neurodegeneration. This study assessed their utility in predicting cognitive decline and as tools for early dementia screening.