Age‐related amyloid‐β dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: cross‐sectional trajectories and longitudinal validation

Abstract

Background: Alzheimer's disease is characterized by early amyloid‐β (Aβ) accumulation, even in cognitively unimpaired (CU) individuals, yet age‐related Aβ trajectories remain poorly understood.