AAIC 2025 Abstract

The HOPE4MCI study: AGB101 treatment normalizes aberrant network activity and slows entorhinal cortex atrophy in patients with amnestic mild cognitive impairment due to Alzheimer's Disease who are ApoE‐4 non‐carriers

Trial in peopleInterventions

Abstract

Background: Hippocampal hyperactivity is a pathological hallmark of Alzheimer's disease (AD) and a prognostic indicator for AD progression and clinical cognitive worsening in amnestic mild cognitive impairment (aMCI).

The paper

Johns Hopkins University; AgeneBio (United States)

AAIC 2025 Abstract, 25 Dec 2025, CC BY

Presented at AAIC 2025

doi.org/10.1002/alz70856_100819