Distinct spatiotemporal patterns of juxtacortical microstructure in Alzheimer's Disease

Abstract

Background: Alzheimer's disease (AD) exhibits heterogeneity in pathological changes involving β‐amyloid (Aβ), tau, neural macrostructure and microstructure. We aimed to evaluate juxtacortical free water fraction (FWF), its correlation with neuropathological severity, and its spatiotemporal pattern using MRI and PET in AD.

The paper