AgingResearch.NewsJoin free

Zanubrutinib

Intervention

1 paper4 findings

MeSH C000629551

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Animals1

Outcomes

4

Wnt/β-catenin signalling

downin mouse cells1

1 study

  1. Zanubrutinib inhibits wnt/β-catenin signalling in mouse cells.

    “Zanubrutinib effectively inhibited BTK phosphorylation and Wnt/β-catenin signaling pathway transduction, and reduced β-catenin entry into the nucleus.”

    Cells

    Zanubrutinib mitigates pulmonary fibrosis in aged mice by targeting the Wnt/β-catenin signaling pathway

    Biochemical pharmacology17 Oct 2025

More on Wnt/β-catenin signalling

Cellular senescence

downin mice1

1 study

  1. Zanubrutinib decreases cellular senescence in mice.

    “significantly reduce the expression of fibrosis markers and senescence markers.”

    Animalsin bleomycin-treated senescent mice

    Zanubrutinib mitigates pulmonary fibrosis in aged mice by targeting the Wnt/β-catenin signaling pathway

    Biochemical pharmacology17 Oct 2025

More on Cellular senescence

Fibrosis markers

downin mice1

1 study

  1. Zanubrutinib decreases fibrosis markers in mice.

    “significantly reduce the expression of fibrosis markers and senescence markers.”

    Animalsin bleomycin-treated senescent mice

    Zanubrutinib mitigates pulmonary fibrosis in aged mice by targeting the Wnt/β-catenin signaling pathway

    Biochemical pharmacology17 Oct 2025

More on Fibrosis markers

Pulmonary fibrosis

downin mice1

1 study

  1. Zanubrutinib decreases pulmonary fibrosis in mice.

    “Zanubrutinib could effectively alleviate bleomycin-induced pulmonary fibrosis in senescent mice”

    Animalsin bleomycin-induced pulmonary fibrosis in senescent mice

    Zanubrutinib mitigates pulmonary fibrosis in aged mice by targeting the Wnt/β-catenin signaling pathway

    Biochemical pharmacology17 Oct 2025

More on Pulmonary fibrosis

Latest

Related