Undernutrition

4 papers10 findings

Outcomes

Pain sensitivity

upin rats1

1 study

Undernutrition increases pain sensitivity in rats.
“tail-flick latencies were reduced from early time points and remained stable thereafter, indicating an early and sustained increase in nociceptive sensitivity.”
Animals4, 25, and 32 weeks
Early adult-onset undernutrition drives duration-dependent changes in locomotion, exploration and pain sensitivity in rats
Physiology & behavior16 May 2026

Exploratory rearing

upin rats1

1 study

Undernutrition increases exploratory rearing in rats.
“crossings and exploratory rearing increased only after prolonged undernutrition.”
Animalsprolonged undernutrition
Early adult-onset undernutrition drives duration-dependent changes in locomotion, exploration and pain sensitivity in rats
Physiology & behavior16 May 2026

Locomotor speed

upin rats1

1 study

Undernutrition increases locomotor speed in rats.
“Locomotor speed and distance increased early without a parallel rise in crossings, whereas crossings and exploratory rearing increased only after prolonged undernutrition.”
Animals4, 25, and 32 weeks
Early adult-onset undernutrition drives duration-dependent changes in locomotion, exploration and pain sensitivity in rats
Physiology & behavior16 May 2026

Oxidative stress and ROS signalling

no changein rats1

1 study

Undernutrition has no effect on oxidative stress and ROS signalling in rats.
“There was no evidence that undernutrition programmed lifespan through oxidative processes in the major organs.”
Animalsin the major organs
The association between birthweight and longevity in the rat is complex and modulated by maternal protein intake during fetal life
FEBS letters30 Jun 2006

Steep cognitive decline

upin humans1OR 1.71

1 study

Undernutrition is associated with steep cognitive decline in humans (OR 1.71, 95% CI 1.06-2.77).
“Baseline undernutrition was associated with a higher probability of belonging to the rapidly decreasing trajectory 1 (odds ratio, 1.71, 95% confidence interval, 1.06-2.77, reference, trajectory 3)”
Humansreference, trajectory 39 yn = 3,852
Undernutrition impacts on cognitive performance trajectories in older adults: The collaborative PROMED-COG pooled cohorts study
Nutrition (Burbank, Los Angeles County, Calif.)19 Mar 2026

Self-reported health

downin humans1

1 study

Undernutrition is associated with self-reported health in humans (β -8.27 (-10.81, -5.73)).
“and SRH [-8.27 (-10.81, -5.73)] compared with well-nourished individuals.”
Humanscompared with well-nourished individuals3 yn = 699
The interplay of nutritional status and physical function on health outcomes in older adults: a longitudinal study in Singapore
The American journal of clinical nutrition22 Jul 2025

Health-related quality of life

downin humans1

1 study

Undernutrition is associated with health-related quality of life in humans (β -0.10 (-0.13, -0.07)).
“lower HRQoL [β (95% CI): -0.10 (-0.13, -0.07)]”
Humanscompared with well-nourished individuals3 yn = 699
The interplay of nutritional status and physical function on health outcomes in older adults: a longitudinal study in Singapore
The American journal of clinical nutrition22 Jul 2025

Loneliness

upin humans1OR 5.13

1 study

Undernutrition is associated with loneliness in humans (OR 5.13 (2.77, 9.53)).
“and loneliness [5.13 (2.77, 9.53)]”
Humanscompared with well-nourished individuals3 yn = 699
The interplay of nutritional status and physical function on health outcomes in older adults: a longitudinal study in Singapore
The American journal of clinical nutrition22 Jul 2025

Depression

upin humans1OR 14.94

1 study

Undernutrition is associated with depression in humans (OR 14.94 (7.63, 29.23)).
“depression [14.94 (7.63, 29.23)]”
Humanscompared with well-nourished individuals3 yn = 699
The interplay of nutritional status and physical function on health outcomes in older adults: a longitudinal study in Singapore
The American journal of clinical nutrition22 Jul 2025