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UNC0646

Intervention

1 paper2 findings

PubChem 53315882ChEBI 124924

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Model organisms1

Outcomes

2

Radioresistance

downin flies1

1 study

  1. UNC0646 decreases radioresistance in flies.

    “Resistance to γ radiation was found to decrease in D. melanogaster receiving UNC0646 with food for 2 weeks.”

    Model organisms2 weeks

    Effect of Histone Lysine Methyltransferase G9a Inhibitor on Lifespan and Radioresistance in Drosophila melanogaster

    Molekuliarnaia biologiia1 Jan 2025

Lifespan

upin flies1

1 study

  1. UNC0646 extends lifespan in flies (+1.6-13.9% average lifespan (p < 0.05)).

    “UNC0646 used at concentrations of 0.1-100 μM exerted a geroprotective effect on females, increasing the average lifespan by 1.6-13.9% (p < 0.05).”

    Model organisms0.1-100 μMfemales

    Effect of Histone Lysine Methyltransferase G9a Inhibitor on Lifespan and Radioresistance in Drosophila melanogaster

    Molekuliarnaia biologiia1 Jan 2025

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