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Trouble falling asleep

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Humans1

Associations

2

Recurrent falls

upin humans1OR 2.54

1 study

  1. Trouble falling asleep raises the risk of recurrent falls in humans (OR 2.54, 95% CI 1.30-4.96).

    “Frequent trouble falling asleep and short sleep duration (< 6 hours) were both associated with higher likelihood of recurrent falls (>=3 falls vs. <=1 fall) (OR=2.54, 95% CI=1.30,4.96; OR=1.80, 95% CI=1.07,3.05).”

    Humansfemales

    SLEEP QUALITY AND DURATION AND RISK OF FALLS IN OLDER ADULT WOMEN: THE STUDY OF WOMEN’S HEALTH ACROSS THE NATION (SWAN)

    GSA 2024 abstract31 Dec 2024

Fall risk

upin humans1RR 1.27

1 study

  1. Trouble falling asleep raises the risk of fall risk in humans (RR 1.27, 95% CI 1.01-1.62).

    “Women who reported frequent (5+ times/week) trouble falling asleep and frequent waking in the middle of the night in 2010-2011 had a 27% (RR=1.27, 95% CI=1.01,1.62) and 24% (RR=1.24, 95% CI=1.01,1.48) increased risk of a subsequent fall.”

    Humansfemales

    SLEEP QUALITY AND DURATION AND RISK OF FALLS IN OLDER ADULT WOMEN: THE STUDY OF WOMEN’S HEALTH ACROSS THE NATION (SWAN)

    GSA 2024 abstract31 Dec 2024

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