Tricyclic antidepressants
3 papers2 findings
- 2 independent labs in 2 countries
- Funders: Agència de Gestió d'Ajuts Universitaris i de Recerca and others
- Humans2
Outcomes
1Hippocampal volume
downin humans1
1 study
Hippocampal volume
downin humans1
Tricyclic antidepressants decrease hippocampal volume in humans (d = -0.27 to -1.31).
“Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = -0.27 to -1.31).”
HumansOCD patients taking TCs vs unmedicated patients
Journal of affective disordersAug 27, 2022
Associations
1Dementia
upin humans1HR 1.82
1 study
Dementia
upin humans1HR 1.82
Tricyclic antidepressants raise the risk of dementia in humans (HR=1.82, 95% CI 1.52-2.18).
“especially MAOIs (HR=2.15,95% confidence interval [CI] 1.39−3.34) and TCAs (HR=1.82, 95% CI 1.52−2.18).”
Humansmajor depressive disordern = 56,423
AAIC 2025 abstractDec 23, 2025
Latest
1 in 12 monthsAAIC 2025 Abstract
Treatments for Depression and the Risk of Dementia: A 23‐Year Cohort Study Using Akrivia Health Secondary Mental Healthcare Data
Cohort study of 56,423 peopleMajor depressive disorder
Journal of Affective Disorders
Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
Cross-sectional study of 2,057 peoplePopulations