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TNB-738

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 3 countries
  • Funders: Agence Nationale de la Recherche and 3 more
  • 4 of 4 findings with company ties
  • Cells1

Outcomes

4

CD38-expressing cells

no changein cells1

1 study

  1. TNB-738 has no effect on CD38-expressing cells in cells.

    “Due to its silenced IgG4 Fc, TNB-738 did not deplete CD38-expressing cells”

    Cellsdue to silenced IgG4 Fc

    TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

    mAbsJan 1, 2022

More on CD38-expressing cells

Sirtuin signaling

upin cells1

1 study

  1. TNB-738 activates sirtuin signaling in cells.

    “and SIRT activities”

    Cells

    TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

    mAbsJan 1, 2022

More on Sirtuin signaling

Intracellular NAD+

upin cells1

1 study

  1. TNB-738 increases intracellular NAD+ in cells.

    “which in turn boosted intracellular NAD+ levels”

    Cells

    TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

    mAbsJan 1, 2022

More on Intracellular NAD+

CD38

downin cells1

1 study

  1. TNB-738 inhibits CD38 in cells.

    “TNB-738 potently inhibited its enzymatic activity”

    Cells

    TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

    mAbsJan 1, 2022

More on CD38

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