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Thermoneutrality

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 3 more
  • Animals1

Outcomes

2

Systemic metabolic variations caused by CR

downin mice1−39%

1 study

  1. Thermoneutrality decreases systemic metabolic variations caused by CR in mice (39%).

    “thermoneutrality reverted 39 and 78% of total systemic or hypothalamic metabolic variations caused by CR, respectively”

    Animalsduring calorie restriction

    Metabolic adaptation to calorie restriction

    Science signaling8 Sep 2020

More on Systemic metabolic variations caused by CR

Hypothalamic metabolic variations caused by CR

downin mice1−78%

1 study

  1. Thermoneutrality decreases hypothalamic metabolic variations caused by CR in mice (78%).

    “thermoneutrality reverted 39 and 78% of total systemic or hypothalamic metabolic variations caused by CR, respectively”

    Animalsduring calorie restrictionhypothalamus

    Metabolic adaptation to calorie restriction

    Science signaling8 Sep 2020

More on Hypothalamic metabolic variations caused by CR

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