Tetrodotoxin
Tetrodotoxin has been studied in 2 papers since 2017: none in people yet, 1 in animals, 1 in cells. The research so far is in animals and cells. The newest paper, Jul 15, 2022: “Aging-associated susceptibility to stress-induced ventricular arrhythmogenesis is attenuated by tetrodotoxin”.
See all 6 papers on tetrodotoxin
At a glance
The findings reach mice, none yet in people. 3 independent labs in 2 countries.
None of its findings points the other way.
- 3 independent labs in 2 countries
- Funders: National Heart, Lung, and Blood Institute and 6 more
- 1 of 4 findings with company ties
- Animals1
- Cells1
What did studies of tetrodotoxin find?
4Studies of tetrodotoxin measured 4 outcomes; the most studied are APD90 (1 study), ventricular fibrillation (1) and action potential duration (1).
APD90
downin rat cells1
1 study
APD90
downin rat cells1
Tetrodotoxin decreases APD90 in isolated ventricular cardiomyocytes with 4-aminopyridine and isoproterenol.
“Low-dose tetrodotoxin (0.5 μM) significantly shortened APD without altering action potential upstroke and prevented 4-aminopyridine-mediated APD prolongation, EADs, and triggered activity.”
Cellsin isolated ventricular cardiomyocytes with 4-aminopyridine and isoproterenolheart0.5 μMmales
Biochemical and biophysical research communications
Ventricular fibrillation
downin rats1
1 study
Ventricular fibrillation
downin rats1
Tetrodotoxin prevents ventricular fibrillation in rats (isoproterenol-challenged isolated perfused hearts).
“Tetrodotoxin pretreatment prevented VF induction by pacing in isoproterenol-challenged hearts.”
Animalsisoproterenol-challenged isolated perfused heartsheartmales
Biochemical and biophysical research communications
Action potential duration
downin C. porcellus cells1
1 study
Action potential duration
downin C. porcellus cells1
Tetrodotoxin decreases action potential duration in C. porcellus cells.
“was shortened by the INaL inhibitors GS967 and tetrodotoxin.”
Cellsventricular myocyte
Journal of applied physiology (Bethesda, Md. : 1985)
Intracellular calcium concentration
downin marmoset cells1
1 study
Intracellular calcium concentration
downin marmoset cells1
Tetrodotoxin decreases intracellular calcium concentration in marmoset cells (electrical field stimulation).
“Electrical field stimulation to cjiN cells increased the intracellular calcium level, which was reversibly blocked by the voltage-gated sodium channel blocker, tetrodotoxin”
Cellselectrical field stimulationinduced neuronal cells
Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors
Molecular brain