Tetrahydrofolic acid

1. Tetrahydrofolic acid extends lifespan in worms.

   “the lifespan of genetically modified αS and Aβ expressing C. elegans was extended by feeding THF”

   Model organismsGenetically modified α-synuclein- and amyloid-β-expressing worms

   Tetrahydrofolic acid accelerates amyloid fibrillization, decreases cytotoxic oligomers and suppresses their toxicity

   International journal of biological macromolecules·19 Dec 2024

1. Tetrahydrofolic acid decreases Toxic oligomer abundance in worm cells.

   “Strikingly, this was accompanied by a reduction in the abundance of toxic oligomers, and these results were confirmed by DB.”

   Cellsα-synuclein and amyloid-β fibrillization

   Tetrahydrofolic acid accelerates amyloid fibrillization, decreases cytotoxic oligomers and suppresses their toxicity

   International journal of biological macromolecules·19 Dec 2024

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