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Tau

Tau has been studied in 4 papers since 2018: 2 trials and 1 observational study in people, 1 in animals. The newest paper, Sep 27, 2024: “Patient-derived tau and amyloid-β facilitate long-term depression in vivo: role of tumour necrosis factor-α and the integrated stress response”.

Intervention

4 papers study it1 findingUpdated

See all 4 papers on tau

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

Mice: a single group. Cells, worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and others
  • Human trial2
  • Humans1
  • Animals1

What did studies of tau find?

1

Studies of tau measured 1 outcome; the most studied are synaptic long-term depression (1 study).

Synaptic long-term depression

upin rats1

1 study

  1. Tau increases synaptic long-term depression in rats (peri-threshold low-frequency electrical stimulation).

    “diffusible tau from Alzheimer's disease or Pick's disease patients' brain aqueous extracts or the secretomes of trisomy of chromosome 21 induced pluripotent stem cell-derived neurons, like Alzheimer's disease brain-derived amyloid-β and synthetic oligomeric amyloid-β, potently enhanced synaptic long-term depression in live rats”

    Animalsperi-threshold low-frequency electrical stimulationdiffusible tau from AD or Pick's disease brain aqueous extracts or trisomy 21 iPSC neuron secretomeshippocampus CA1males

    Patient-derived tau and amyloid-β facilitate long-term depression in vivo: role of tumour necrosis factor-α and the integrated stress response

    Brain communications

Funding

179 grants since 2016

National Institute on Aging$397MNational Institute of Neurological Disorders and Stroke$11.9MAlzheimer's Association

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